Chloroform → Methyl 4-bromo-3-oxopentanoate

Temperatur

0 °C

Under a nitrogen atmosphere, a solution of bromine (8.61 mL, 167 mmol) in chloroform (20 mL, 200 mmol) was added dropwise over a period of 2 h to a solution of 3-oxopentanoic acid, methyl ester (Aldrich, 21.0 mL, 167 mmol) in chloroform (147 mL, 1840 mmol), at 0° C. (ice bath). The reaction mixture was stirred for 30 min at 0° C. and then allowed to stand at room temperature overnight. While stirring, a stream of air was bubbled through the solution for 1 hour. After drying over sodium sulfate, the solvent was evaporated under reduced pressure leaving the desired compound.

1. waitto stand at room temperature overnight
2. stirringWhile stirring
3. customa stream of air was bubbled through the solution for 1 hour
4. dry with materialAfter drying over sodium sulfate
5. customthe solvent was evaporated under reduced pressure

ORD-Eintrag

ord-86862d0fe81b4e928e2e6e241f99f422

Quelldatensatz

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09434746B2