StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Sodium Iodide → 1-Benzoyloxymethyl-5-bromo-6-ethyl-4-[2-(2,4-dimethylphenoxy)-propylamino]pyrimidinium iodide

HRID 582547
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 582547
[Br:1][C:2]1[C:3]([NH:10][CH2:11][CH:12]([O:14][C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:16]=2[CH3:22])[CH3:13])=[N:4][CH:5]=[N:6][C:7]=1[CH2:8][CH3:9].[C:23]([O:31][CH2:32]Cl)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[I-:34].[Na+]>CC(C)=O>[I-:34].[C:23]([O:31][CH2:32][N+:6]1[C:7]([CH2:8][CH3:9])=[C:2]([Br:1])[C:3]([NH:10][CH2:11][CH:12]([O:14][C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:16]=2[CH3:22])[CH3:13])=[N:4][CH:5]=1)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

5

Edukt 3

HCID 5238Sodium IodideHCID 79257Chloromethyl benzoateHCID 537398875-Bromo-6-ethyl-4-[2-(2,4-dimethylphenoxy)-propylamino]pyrimidine

Produkt 1

HCID 675994591-Benzoyloxymethyl-5-bromo-6-ethyl-4-[2-(2,4-dimethylphenoxy)-propylamino]pyrimidinium iodide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

0.3 g (8.2 mmol) of 5-bromo-6-ethyl-4-[2-(2,4-dimethylphenoxy)-propylamino]pyrimidine (according to EP-A-57 440), 0.17 g (9.8 mmol) of chloromethyl benzoate and 0.12 g (8.2 mmol) of sodium iodide in 25 ml of acetone were heated under reflux for 8 hours. After cooling, the precipitated sodium chloride was filtered off and the filtrate was concentrated. The residue was taken up in dichloromethane and washed by stirring with water. The organic phase was dried and concentrated. The residue was digested with ethyl acetate. Filtration with suction gave 0.97 g (53.3% of theory) of light-yellow crystals. mp.: 159-161° C.

Aufarbeitung

  1. temperatureunder reflux for 8 hours
  2. temperatureAfter cooling
  3. filtrationthe precipitated sodium chloride was filtered off
  4. concentrationthe filtrate was concentrated
  5. washwashed
  6. customThe organic phase was dried
  7. concentrationconcentrated
  8. filtrationFiltration with suction
  9. customgave 0.97 g (53.3% of theory) of light-yellow crystals

Quellen und Nachweise

ORD-Eintrag
ord-f8a076c500ce4ebcb8ed728ba249b303
Quelldatensatz
uspto-grants-1999_07
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05925644

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion