Benzyl 1-(2-(isopentylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate → 2-(3-Amino-2-oxopyridin-1(2H)-yl)-N-isopentylacetamide

HRID 58321

Reaktionsgleichung

Reaktionsgleichung von HRID 58321
[CH2:1]([NH:6][C:7](=[O:27])[CH2:8][N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15]C(=O)OCC2C=CC=CC=2)[C:10]1=[O:26])[CH2:2][CH:3]([CH3:5])[CH3:4]>C(O)C.[Pd]>[NH2:15][C:11]1[C:10](=[O:26])[N:9]([CH2:8][C:7]([NH:6][CH2:1][CH2:2][CH:3]([CH3:4])[CH3:5])=[O:27])[CH:14]=[CH:13][CH:12]=1

Komponenten

4

Edukt 1

HCID 89926023Benzyl 1-(2-(isopentylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate

Produkt 1

HCID 621027802-(3-Amino-2-oxopyridin-1(2H)-yl)-N-isopentylacetamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

573 mg of benzyl 1-(2-(isopentylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate (ZED1020, 1.54 mmol) are dissolved under nitrogen atmosphere in 100 mL of ethanol. To this solution 50 mg of Pd/C (10%) is added and stirred under hydrogen atmosphere at atmosphere pressure for 1 h at RT. The catalysis is separated by filtration over silica gel, before the solvent is removed in vacuo. Green solid is obtained and it is suitable for further processing without purification.

Aufarbeitung

  1. customThe catalysis is separated by filtration over silica gel, before the solvent
  2. customis removed in vacuo
  3. customGreen solid is obtained
  4. customit is suitable for further processing without purification

Quellen und Nachweise

ORD-Eintrag
ord-e04a6a6bdfb94eadbe3d12bb628ca028
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434763B2

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