(3-Benzyloxycarbonylamino-2-oxo-2h-pyridin-1-yl)acetic acid tert-butyl ester → 3-Amino-1-(tert-butoxycarbonylmethyl)-2-pyridinone

HRID 58322Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 58322
C(OC([NH:11][C:12]1[C:13](=[O:26])[N:14]([CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH:15]=[CH:16][CH:17]=1)=O)C1C=CC=CC=1>C(O)C.[Pd]>[NH2:11][C:12]1[C:13](=[O:26])[N:14]([CH2:18][C:19]([O:21][C:22]([CH3:24])([CH3:23])[CH3:25])=[O:20])[CH:15]=[CH:16][CH:17]=1

Komponenten

4

Edukt 1

HCID 70027044(3-Benzyloxycarbonylamino-2-oxo-2h-pyridin-1-yl)acetic acid tert-butyl ester

Produkt 1

HCID 44562653-Amino-1-(tert-butoxycarbonylmethyl)-2-pyridinone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

2.00 g of tert-butyl 2-(3-(benzyloxycarbonylamino)-2-oxopyridin-1(2H)-yl)acetate are dissolved under nitrogen atmosphere in 70 mL of ethanol. To this solution 200 mg of Pd/C (10%) is added and stirred under hydrogen atmosphere at atmosphere pressure for 1.5 h at RT. The catalysis is separated by filtration over silica gel, before the solvent is removed in vacuo. The crude product is used for further processing without purification.

Aufarbeitung

  1. customThe catalysis is separated by filtration over silica gel, before the solvent
  2. customis removed in vacuo
  3. customThe crude product is used for further processing without purification

Quellen und Nachweise

ORD-Eintrag
ord-4384503b863c445485bff3a0d4e24490
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434763B2

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