4-(3-Bromo-4-methoxyphenoxy)-3,5-dimethylnitrobenzene → 4-(3-Bromo-4-methoxy-phenoxy)-3,5-dimethyl-phenylamine

HRID 584037Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 584037
[Br:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[O:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([N+:13]([O-])=O)=[CH:8][C:7]=1[CH3:16]>[Pd].C(OCC)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[O:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([NH2:13])=[CH:8][C:7]=1[CH3:16]

Komponenten

4

Edukt 1

HCID 223397284-(3-Bromo-4-methoxyphenoxy)-3,5-dimethylnitrobenzene

Produkt 1

HCID 223395024-(3-Bromo-4-methoxy-phenoxy)-3,5-dimethyl-phenylamineAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of the title product of Step A (5.0 g) and 10% palladium on carbon (0.6 g) in ethyl acetate (100 ml) was hydrogenated at 50 psi for 3 h. The reaction was filtered through Celite and concentrated to afford the title compound of Step B as a yellow solid (4.3 g). MS (APCl+) Calc: 321; Found 322 (M+1).

Aufarbeitung

  1. filtrationThe reaction was filtered through Celite
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-72fd1386b1924835a94407742935102a
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06924310B2

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