2-Methyl-2-butanol → Dasabuvir

HRID 58406

Reaktionsgleichung

Reaktionsgleichung von HRID 58406
C(P(C(C)(C)C)C1C(OC)=CC=C(OC)C=1C1C(C(C)C)=CC(C(C)C)=CC=1C(C)C)(C)(C)C.[O-]P([O-])([O-])=O.[K+].[K+].[K+].C(O)(CC)(C)C.FC(F)(S(O[C:65]1[CH:74]=[CH:73][C:72]2[C:67](=[CH:68][CH:69]=[C:70]([C:75]3[CH:80]=[C:79]([N:81]4[CH:86]=[CH:85][C:84](=[O:87])[NH:83][C:82]4=[O:88])[CH:78]=[C:77]([C:89]([CH3:92])([CH3:91])[CH3:90])[C:76]=3[O:93][CH3:94])[CH:71]=2)[CH:66]=1)(=O)=O)C(F)(F)C(F)(F)C(F)(F)F.[CH3:96][S:97]([NH2:100])(=[O:99])=[O:98]>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[C:89]([C:77]1[C:76]([O:93][CH3:94])=[C:75]([C:70]2[CH:71]=[C:72]3[C:67](=[CH:68][CH:69]=2)[CH:66]=[C:65]([NH:100][S:97]([CH3:96])(=[O:99])=[O:98])[CH:74]=[CH:73]3)[CH:80]=[C:79]([N:81]2[CH:86]=[CH:85][C:84](=[O:87])[NH:83][C:82]2=[O:88])[CH:78]=1)([CH3:91])([CH3:90])[CH3:92]

Komponenten

7

Edukt 5

HCID 64052-Methyl-2-butanol2×HCID 62657Potassium Phosphate, TribasicHCID 72879MethanesulfonamideHCID 44233348Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-(1,1'-biphenyl)-2-yl)phosphineHCID 566406691-Butanesulfonic acid, 1,1,2,2,3,3,4,4,4-nonafluoro-, 6-(5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl)-2-naphthalenyl ester

Produkt 1

HCID 56640146Dasabuvir

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 9811564Bis(dibenzylideneacetone)palladiumKatalysator

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Tris(dibenzylideneacetone)dipalladium(0) (0.0066 g, 7.16 μmol), di-tert-butyl(2′,4′,6′-triisopropyl-3,6-dimethoxybiphenyl-2-yl)phosphine (0.0083 g, 17 μmol) and milled potassium phosphate tribasic (0.334 g, 1.58 mmol) were charged to a 40-mL reaction vial inside an inert atmosphere glove box. t-Amyl alcohol (4 mL) was added, the vial was capped, and the contents were heated to 80° C. and stirred at this temperature for 30 minutes. The reaction mixture was cooled down to the room temperature. 6-(3-tert-Butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate (1.0 g, 1.43 mmol), methanesulfonamide (0.163 g, 1.72 mmol) and t-amyl alcohol (8 mL) were added to the 40-mL reaction vial, and the vial was capped. The reaction temperature was raised to 90° C. and the contents were stirred for 5 hours. HPLC analysis of the reaction mixture showed that the product was formed in 94 area % at 210 nm.

Aufarbeitung

  1. additionwere charged to a 40-mL reaction vial inside an inert atmosphere glove box
  2. customthe vial was capped
  3. temperatureThe reaction mixture was cooled down to the room temperature
  4. customthe vial was capped
  5. temperatureThe reaction temperature was raised to 90° C.
  6. stirringthe contents were stirred for 5 hours
  7. customwas formed in 94 area % at 210 nm

Quellen und Nachweise

ORD-Eintrag
ord-dfb4cd3bda804dacb31b92974c6d4431
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434698B2

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