Phosphorus oxychloride → 2,6,7-Trichloro-3-methylquinoxaline
Reaktionsgleichung
O=P(Cl)(Cl)[Cl:3].[Cl:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][C:16]=1[Cl:17])[NH:13][C:12](=O)[C:11]([CH3:19])=[N:10]2>CN(C)C1C=CN=CC=1>[Cl:3][C:12]1[C:11]([CH3:19])=[N:10][C:9]2[C:14](=[CH:15][C:16]([Cl:17])=[C:7]([Cl:6])[CH:8]=2)[N:13]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
POCl3 was added to 6,7-Dichloro-3-methyl-1H-quinoxalin-2-one (10 g, 44 mmol) and 4-dimethylaminopyridine (1 g) and the mixture was refluxed for 0.5 hours. After cooling, the mixture was poured onto ice (500 ml), filtered and washed with water to afford the title compound.
Aufarbeitung
- temperaturethe mixture was refluxed for 0.5 hours
- temperatureAfter cooling
- additionthe mixture was poured onto ice (500 ml)
- filtrationfiltered
- washwashed with water
Quellen und Nachweise
- ORD-Eintrag
- ord-aa24519db1d843c2a38169ddc639d1c3
- Quelldatensatz
- uspto-grants-2005_08
- Patentnummer
- US06927214B1
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