Phosphorus oxychloride → 2-Chloro-6,7-difluoro-3-methylquinoxaline
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[NH:8][C:7](=O)[C:6]([CH3:14])=[N:5]2.O=P(Cl)(Cl)[Cl:17]>CN(C)C1C=CN=CC=1>[Cl:17][C:7]1[C:6]([CH3:14])=[N:5][C:4]2[C:9](=[CH:10][C:11]([F:12])=[C:2]([F:1])[CH:3]=2)[N:8]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
6,7-Difluoro-3-methyl-1H-quinoxalin-2-one (2 g, prepared from 4,5-difluoro-1,2-phenylene-diamine and pyruvic acid according to general procedure (A), step 1) was mixed with POCl3 (20 ml) and 4-dimethylaminopyridine (10 mol %) and the mixture was refluxed for 2 hours. The mixture was allowed to cool and poured onto ice (300 ml), filtered and washed with water to afford the title compound.
Aufarbeitung
- temperaturethe mixture was refluxed for 2 hours
- temperatureto cool
- additionpoured onto ice (300 ml)
- filtrationfiltered
- washwashed with water
Quellen und Nachweise
- ORD-Eintrag
- ord-9e777484c7d441c3b6d1d48e99f1e23d
- Quelldatensatz
- uspto-grants-2005_08
- Patentnummer
- US06927214B1
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