Potassium Nitrate → 5-Bromo-8-nitroisoquinoline

HRID 585911

Reaktionsgleichung

Reaktionsgleichung von HRID 585911
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[N+:12]([O-])([O-:14])=[O:13].[K+]>[OH-].[NH4+]>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2

Komponenten

4

Edukt 2

HCID 24434Potassium NitrateHCID 7364875-Bromoisoquinoline

Produkt 1

HCID 8169835-Bromo-8-nitroisoquinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14923Ammonium HydroxideLösungsmittel

Versuchsvorschrift

The diethyl ether solution from Example 57A was treated with potassium nitrate (10.1 g, 100 mmol). After stirring for one hour, The mixture was poured onto ice and neutralized with concentrated ammonium hydroxide (˜300 ml). The crude product was collected by filtration, dried, and recrystalization from methanol to provide the title compound (8.83 g).

Aufarbeitung

  1. filtrationThe crude product was collected by filtration
  2. customdried
  3. customrecrystalization from methanol

Quellen und Nachweise

ORD-Eintrag
ord-8378bd2b8abd47ef93fa966ae2e38faa
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06933311B2

Verknüpfte Notizen

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