Water → 4-Morpholinobenzylamine

HRID 585924

Reaktionsgleichung

Reaktionsgleichung von HRID 585924
[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+].O>C1COCC1>[N:1]1([C:7]2[CH:8]=[CH:9][C:10]([CH2:11][NH2:12])=[CH:13][CH:14]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 3948084-MorpholinobenzonitrileHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 27764584-MorpholinobenzylamineAusbeute 23 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The product from Example 66A (1.24 g, 6.6 mmol) in THF (25 mL) was treated with LiAlH4 (2.5 g, 65.9 mmol) at 0° C. The mixture was allowed to warm to room temperature and then refluxed for 1 hour. The mixture was allowed to cool to room temperature and then treated with 1N NaOH carefully followed by water. The mixture was concentrated under reduced pressure and the resulting aqueous mixture was extracted with diethyl ether. The organic extracts were combined, washed with saturated NaHCO3 solution, dried over Na2SO4, filtered, and the filtrate concentrated under reduced pressure to provide the title compound as a yellow oil (286 mg, 23%).

Aufarbeitung

  1. temperaturerefluxed for 1 hour
  2. temperatureto cool to room temperature
  3. concentrationThe mixture was concentrated under reduced pressure
  4. extractionthe resulting aqueous mixture was extracted with diethyl ether
  5. washwashed with saturated NaHCO3 solution
  6. dry with materialdried over Na2SO4
  7. filtrationfiltered
  8. concentrationthe filtrate concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e8c97ca82e4b4735a58fc755a8cf80fe
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06933311B2

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