1-Methyl-4-nitro-1H-indazole → 1H-Indazol-4-amine, 1-methyl-

HRID 586073

Reaktionsgleichung

Reaktionsgleichung von HRID 586073
[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([N+:11]([O-])=O)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3]1.[H][H]>C(O)C.[Pd].[C]>[CH3:1][N:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([NH2:11])[C:5]=2[CH:4]=[N:3]1

Komponenten

5

Edukt 2

HCID 2802131-Methyl-4-nitro-1H-indazoleHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 1538381H-Indazol-4-amine, 1-methyl-

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

1-Methyl-4-nitro-1H-indazole (6.1 g; 35.4 mmol) and 10% Pd/carbon (500 mg) were combined in ethanol and hydrogenated in a Parr apparatus at 60 PSI hydrogen at 50° C. for 1 hour. The mixture was allowed to cool to ambient temperature, filtered through Celite, and concentrated under reduced pressure to provide the title compound. 1H NMR (DMSO-d6) δ 8.02 (s, 1H), 7.02 (t, 1H), 6.62 (d, 1H), 6.14 (d, 1H), 5.75 (s, 2H), 3.90 (s, 2H).

Aufarbeitung

  1. filtrationfiltered through Celite
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-487ba7571ac24c22a48de22de3da1e24
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06933311B2

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