Acetic Anhydride → HCID 10149094, Verbindung

HRID 586752Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 586752
C(O[C:5](=[O:7])[CH3:6])(=O)C.C(N(CC)CC)C.[NH2:15][C:16]1[N:24]=[C:23]2[C:19]([NH:20][CH:21]=[N:22]2)=[C:18]([Cl:25])[N:17]=1>C1(C)C=CC=CC=1>[C:5]([N:22]1[CH:21]=[N:20][C:19]2[C:23]1=[N:24][C:16]([NH2:15])=[N:17][C:18]=2[Cl:25])(=[O:7])[CH3:6]

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 53603492-Amino-6-chloropurine

Produkt 1

HCID 10149094HCID 10149094, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 204.2 g (2.00 mol) of acetic anhydride, 202.4 g (2.00 mol) of triethylamine and 169.6 g (1.00 mol) of 2-amino-6-chloropurine was stirred at 80° C. for 1 hour. The resulting suspension was cooled at 25° C., and thereafter diluted with 400 mL of toluene, and the diluted solution was filtered. The resulting crystals were suspended in 300 mL of isopropanol, and the suspension was filtered again. The resulting crystals were dried at 60° C. under reduced pressure, to give 211.8 g of white powder of 9-acetyl-2-amino-6-chloropurine (yield 100%).

Aufarbeitung

  1. temperatureThe resulting suspension was cooled at 25° C.
  2. filtrationthe diluted solution was filtered
  3. filtrationthe suspension was filtered again
  4. customThe resulting crystals were dried at 60° C. under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c52926e774bb404f88c5c021b7c45a74
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06936713B2

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