3-Hydroxybenzaldehyde → 3-Propoxybenzaldehyde

HRID 587001

Reaktionsgleichung

Reaktionsgleichung von HRID 587001
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][CH2:18][CH3:19].O>CN(C=O)C>[CH2:17]([O:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6])[CH2:18][CH3:19]

Komponenten

6

Edukt 4

HCID 1013-HydroxybenzaldehydeHCID 962WaterHCID 78401-BromopropaneHCID 11430Potassium Carbonate

Produkt 1

HCID 27604693-PropoxybenzaldehydeAusbeute 99,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 3-hydroxybenzaldehyde (10.0 g) in DMF (120 ml) were added potassium carbonate (15.8 g) and 1-bromopropane (12.1 g), and the mixture was stirred under nitrogen atmosphere at room temperature overnight. Then, water was added to the mixture, which was extracted with ethyl acetate and washed with 1N sodium hydroxide solution twice, with water three times and with saturated brine once. After dried with magnesium sulfate, the solvent was evaporated under reduced pressure to give 3-propoxybenzaldehyde (13.4 g) as colorless liquid.

Aufarbeitung

  1. extractionwas extracted with ethyl acetate
  2. washwashed with 1N sodium hydroxide solution twice
  3. dry with materialAfter dried with magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e532573e9813427585e1ab5d71970579
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06936602B1

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