Hydrochloric Acid → 2-(2-Methyl-1,3-dioxolan-2-yl)acetic acid

HRID 587027Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 587027
[CH3:1][C:2]1([CH2:7][C:8]([O:10]CC)=[O:9])[O:6][CH2:5][CH2:4][O:3]1.[OH-].[Na+].Cl>CO>[CH3:1][C:2]1([CH2:7][C:8]([OH:10])=[O:9])[O:6][CH2:5][CH2:4][O:3]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 80865Ethyl acetoacetate ethyleneglycol ketal

Produkt 1

HCID 5600442-(2-Methyl-1,3-dioxolan-2-yl)acetic acidAusbeute 97,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of ethyl 2-methyldioxolan-2-ylacetate (2.0 g) in methanol (69 ml) was added 1N sodium hydroxide solution (23 ml), and the mixture was stirred at room temperature overnight. Then, the mixture was neutralized with 1N hydrochloric acid, and the solvent was evaporated under reduced pressure. To the mixture was added ethyl acetate, and the mixture was dried with magnesium sulfate. The solvent was evaporated under reduced pressure to give 2-methyldioxolan-2-ylacetic acid (1.63 g) as colorless

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure
  2. additionTo the mixture was added ethyl acetate
  3. dry with materialthe mixture was dried with magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-39d1a3e036c64798b046a20b7c1fecd1
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06936602B1

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