Ethyl chloroformate → Ethyl 2-chloroimidazo[1,2-a]pyridine-3-carboxylate

HRID 587463Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 587463
C([Li])CCC.[Cl:6][C:7]1[N:8]=[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]2[CH:15]=1.[C:16](Cl)(=[O:20])[O:17][CH2:18][CH3:19]>C1COCC1>[Cl:6][C:7]1[N:8]=[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]2[C:15]=1[C:16]([O:17][CH2:18][CH3:19])=[O:20]

Komponenten

5

Edukt 3

HCID 10928Ethyl chloroformateHCID 21139722-Chloroimidazo[1,2-a]pyridineHCID 178418339Butyllithium

Produkt 1

HCID 21643308Ethyl 2-chloroimidazo[1,2-a]pyridine-3-carboxylateAusbeute 89,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

n-Butyllithium (1.6M in hexane, 45.1 mL) was added to a solution of 2-chloroimidazo[1,2-a]pyridine (10 g) in THF (120 mL) at −78° C. After stirring for 30 min, ethyl chlorocarbonate (7.82 g) in THF (10 mL) was added to the mixture at the same temperature and stirred for 1 h and then 10 h at room temperature. The mixture was quenched with water, and extracted with ethyl acetate, and the extract was washed with brine, and dried over magnesium sulfate. The residue was purified by column chromatography (silica gel, eluted with 10%-50% EtOAc in hexane) to give ethyl 2-chloroimidazo[1,2-a]pyridine-3-carboxylate (13.20 g) as an off-white solid.

Aufarbeitung

  1. stirringstirred for 1 h
  2. custom10 h
  3. customat room temperature
  4. customThe mixture was quenched with water
  5. extractionextracted with ethyl acetate
  6. washthe extract was washed with brine
  7. dry with materialdried over magnesium sulfate
  8. customThe residue was purified by column chromatography (silica gel, eluted with 10%-50% EtOAc in hexane)

Quellen und Nachweise

ORD-Eintrag
ord-c628f106f9554e0d88e3933fc7b13c76
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09226921B2

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