N-benzyl-N-methyl-3-nitropyridin-2-amine → 2-N-methylpyridine-2,3-diamine
Reaktionsgleichung
[CH2:1]([N:8](C)[C:9]1[C:14]([N+:15]([O-])=O)=[CH:13][CH:12]=[CH:11][N:10]=1)C1C=CC=CC=1>CCO.[Pd]>[CH3:1][NH:8][C:9]1[C:14]([NH2:15])=[CH:13][CH:12]=[CH:11][N:10]=1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A mixture of N-benzyl-N-methyl-3-nitropyridin-2-amine (15 g) and 10% Pd—C (6.56 g) in EtOH (300 mL) was hydrogenated under balloon pressure at room temperature over weekend. The catalyst was removed by filtration and the filtrate was concentrated in vacuo to give N2-methylpyridine-2,3-diamine (7.00 g) as a tan solid.
Aufarbeitung
- waitwas hydrogenated under balloon pressure at room temperature over weekend
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-3cb753d45eac47a4b4ed75133c0e2952
- Quelldatensatz
- uspto-grants-2016_01
- Patentnummer
- US09226921B2
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