Hydrochloric Acid → 2-Amino-6-bromo-4-fluoro-3-nitrophenol

HRID 589132Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 589132
[Br:1][C:2]1[C:7]([OH:8])=[C:6]([N+:9]([O-])=O)[C:5]([N+:12]([O-:14])=[O:13])=[C:4]([F:15])[CH:3]=1.Cl>CO.O>[NH2:9][C:6]1[C:5]([N+:12]([O-:14])=[O:13])=[C:4]([F:15])[CH:3]=[C:2]([Br:1])[C:7]=1[OH:8]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 90410240HCID 90410240, Verbindung

Produkt 1

HCID 904098182-Amino-6-bromo-4-fluoro-3-nitrophenol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

6-Bromo-4-fluoro-2,3-dinitrophenol (4.4 g, 16 mmol) was stirred in methanol (88 mL) and 12.0 M hydrogen chloride in water (40 mL), followed by addition of stannous chloride dihydrate (11 g, 47 mmol) and the mixture was stirred at room temperature for 15 min. The mixture was diluted with water and extracted with ethyl acetate. The organic layer was separated and concentrated. Purification on silica gel eluting ethyl acetate in hexanes gave the amine product.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. customThe organic layer was separated
  3. concentrationconcentrated
  4. customPurification on silica gel
  5. washeluting ethyl acetate in hexanes

Quellen und Nachweise

ORD-Eintrag
ord-a566e1f55c614dc2855a42c62da85f4a
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09227985B2

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