Ammonium Hydroxide → 5-Chloropyrazolo[1,5-a]pyrimidin-7-amine

HRID 589153

Reaktionsgleichung

Reaktionsgleichung von HRID 589153
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=1.[NH4+:12].[OH-]>>[Cl:1][C:2]1[CH:7]=[C:6]([NH2:12])[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=1

Komponenten

3

Edukt 2

HCID 14923Ammonium HydroxideHCID 110741545,7-Dichloropyrazolo[1,5-a]pyrimidine

Produkt 1

HCID 231319095-Chloropyrazolo[1,5-a]pyrimidin-7-amine

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

To 5,7-dichloropyrazolo[1,5-a]pyrimidine (7.6 g, 40.4 mmol) in a sealed vessel was added NH4OH (100 mL). The vessel was then sealed and heated at 85° C. for 2.5 hours, at which time the consistency of the white solid had changed (from foamy white solid to free-flowing white solid). The vessel was removed from the heat source and allowed to cool to room temperature overnight. On cooling, the contents of the vessel were collected and dried by vacuum filtration giving 5-chloropyrazolo[1,5-a]pyrimidin-7-amine as a yellow-tinged white solid (6.8 g).

Aufarbeitung

  1. customThe vessel was then sealed
  2. customThe vessel was removed from the heat source
  3. temperatureto cool to room temperature overnight
  4. temperatureOn cooling
  5. customthe contents of the vessel were collected
  6. customdried by vacuum filtration

Quellen und Nachweise

ORD-Eintrag
ord-62ddcfe51f8a41c18e1c5170c8284292
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09227971B2

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