ethyl 2-[3-(4-nitrobenzyl)-1H-indazol-1-yl]acetate → ethyl 2-[3-(4-aminobenzyl)-1H-indazol-1-yl]acetate

HRID 589348Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 589348
[N+:1]([C:4]1[CH:25]=[CH:24][C:7]([CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:10]=2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:10]=2)=[CH:24][CH:25]=1

Komponenten

4

Edukt 1

HCID 89590255ethyl 2-[3-(4-nitrobenzyl)-1H-indazol-1-yl]acetate

Produkt 1

HCID 89590284ethyl 2-[3-(4-aminobenzyl)-1H-indazol-1-yl]acetateAusbeute 53,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1.3 g (3.83 mmol) ethyl 2-[3-(4-nitrobenzyl)-1H-indazol-1-yl]acetate was dissolved in 40 mL methanol. 200 mg palladium on carbon was added, and reacted under an atmosphere of H2 at room temperature overnight. It was filtered to remove solid, rotate evaporated to dryness to remove the solvent, and separated by a preparative chromatography to obtain a white solid 630 mg, at a yield of 53.3%.

Aufarbeitung

  1. customreacted under an atmosphere of H2 at room temperature overnight
  2. filtrationIt was filtered
  3. customto remove solid
  4. customrotate evaporated to dryness
  5. customto remove the solvent
  6. customseparated by a preparative chromatography

Quellen und Nachweise

ORD-Eintrag
ord-3980d90367aa4ddeb7b4f496eaec4e9a
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09233098B2

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