Oxalyl chloride → 6-Fluoro-2-naphthoyl chloride

HRID 589385

Reaktionsgleichung

Reaktionsgleichung von HRID 589385
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([OH:14])=O)[CH:6]=[CH:5]2.C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([Cl:18])=[O:14])[CH:6]=[CH:5]2

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 27827886-Fluoro-2-naphthoic acid

Produkt 1

HCID 866748346-Fluoro-2-naphthoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

6-Fluoro-2-naphthoic acid (228 mg, 1.2 mmol) was dissolved in dichloromethane (15 mL) and N,N-dimethylformamide (0.1 mL), and in an ice bath oxalic chloride (228 mg, 1.8 mmol) was added dropwise slowly. Upon completion of the dropwise addition, it was moved to react at room temperature for 3 hours, and concentrated under reduce pressure to obtain a white solid, i.e. 6-fluoro-2-naphthoyl chloride.

Aufarbeitung

  1. additionUpon completion of the dropwise addition, it
  2. customto react at room temperature for 3 hours
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-a0b272b1e5734728a4e677fa84822678
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09233098B2

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