Oxalyl chloride → HCID 82371400, Verbindung

HRID 589623Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 589623
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:11]=[C:10]([C:12]([OH:14])=O)[O:9][N:8]=2)[CH:2]=1.C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:11]=[C:10]([C:12]([Cl:18])=[O:14])[O:9][N:8]=2)[CH:2]=1

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 290785823-(3-Pyridinyl)-5-isoxazolecarboxylic acid

Produkt 1

HCID 82371400HCID 82371400, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

600 mg (3.16 mmol) of 3-(pyridin-3-yl)-1,2-oxazole-5-carboxylic acid were initially charged in dichloromethane, and three drops of DMF were added. 1.16 g (9.15 mmol) of oxalyl chloride were added dropwise under argon (vigorous evolution of gas). The reaction solution was stirred at room temperature and then the solvent was removed on a rotary evaporator. 30 ml of toluene were added to the residue. After the toluene had been removed on a rotary evaporator, the residue was converted further directly.

Aufarbeitung

  1. customthe solvent was removed on a rotary evaporator
  2. addition30 ml of toluene were added to the residue
  3. customAfter the toluene had been removed on a rotary evaporator

Quellen und Nachweise

ORD-Eintrag
ord-1b8b0257fd81439c80551f19f08bec0a
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09233951B2

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