Phosphorus oxychloride → 5-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of 5-fluoro-3-methylbenzothiophene-2-sulfonic acid (230 mg, 0.93 mmol) in POCl3 (5 mL) was heated at 60° C. over night. The POCl3 was evaporated and the crude product was dissolved in CH2Cl2 and washed with water. The organic phase was dried and evaporated to give 0.23 g (93%) of the title compound.

Herkunft & Nachweise