Phosphorus oxychloride → 5-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride

HRID 589670Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 589670
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10](O)(=[O:12])=[O:11])=[C:7]([CH3:14])[C:6]=2[CH:15]=1.O=P(Cl)(Cl)[Cl:18]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10]([Cl:18])(=[O:12])=[O:11])=[C:7]([CH3:14])[C:6]=2[CH:15]=1

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 178554105-Fluoro-3-methylbenzothiophene-2-sulfonic acid

Produkt 1

HCID 27745865-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chlorideAusbeute 93 %

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 5-fluoro-3-methylbenzothiophene-2-sulfonic acid (230 mg, 0.93 mmol) in POCl3 (5 mL) was heated at 60° C. over night. The POCl3 was evaporated and the crude product was dissolved in CH2Cl2 and washed with water. The organic phase was dried and evaporated to give 0.23 g (93%) of the title compound.

Aufarbeitung

  1. customThe POCl3 was evaporated
  2. dissolutionthe crude product was dissolved in CH2Cl2
  3. washwashed with water
  4. customThe organic phase was dried
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-fe9222313f924dadb315294cf65a9697
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09233946B2

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