5-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride → HCID 178432000, Verbindung

HRID 589710

Reaktionsgleichung

Reaktionsgleichung von HRID 589710
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10](Cl)(=[O:12])=[O:11])=[C:7]([CH3:14])[C:6]=2[CH:15]=1.[NH2:16][C:17]1[CH:18]=[C:19]([C:23]2[NH:27][N:26]=[N:25][N:24]=2)[CH:20]=[CH:21][CH:22]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]4[NH:27][N:26]=[N:25][N:24]=4)[CH:18]=3)(=[O:12])=[O:11])=[C:7]([CH3:14])[C:6]=2[CH:15]=1

Komponenten

3

Edukt 2

HCID 27745865-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride2×HCID 178507542HCID 178507542, Verbindung

Produkt 1

HCID 178432000HCID 178432000, VerbindungAusbeute 36 %

Versuchsvorschrift

The product was prepared according to General Procedure 1, described in Example 1, starting from 5-fluoro-3-methylbenzothiophene-2-sulfonyl chloride (Intermediate 14) (26 mg, 0.10 mmol) and 5-(3-amino-phenyl)tetrazole (31 mg, 0.19 mmol). The title compound was obtained in 36% yield (13.9 mg). MS (ESI+) calcd for C16H12FN5O2S2 389.041644, found 389.042334.

Aufarbeitung

  1. customThe product was prepared

Quellen und Nachweise

ORD-Eintrag
ord-e81738f6c1474d4689b642b53cd9f48a
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09233946B2

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