HCID 118271795, Verbindung → (αS)-α-(1-Methoxy-1-methylethyl)benzenemethanamine

HRID 590792Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 590792
[CH3:1][O:2][C:3]([CH3:31])([CH3:30])[C@H:4]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[N:5](CC1C=CC(OC)=CC=1)CC1C=CC(OC)=CC=1>CO.[Pd]>[CH3:1][O:2][C:3]([CH3:31])([CH3:30])[C@H:4]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[NH2:5]

Komponenten

4

Edukt 1

HCID 118271795HCID 118271795, Verbindung

Produkt 1

HCID 57791001(αS)-α-(1-Methoxy-1-methylethyl)benzenemethanamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of (S)-2-methoxy-N,N-bis(4-methoxybenzyl)-2-methyl-1-phenylpropan-1-amine (0.7 g, 1.67 mmol) in anhydrous MeOH was added Pd on C (0.1 g) and the contents were stirred at ambient temperature in H2 atmosphere. After 14 h, the reaction mixture was filtered through a pad of celite and the volatiles were removed under reduced pressure. The residue thus obtained was further purified by preparative HPLC to afford the title compound. H1NMR (ppm, 400 MHz, CDCl3) δ 7.45-7.44 (m, 2H), 7.35-7.33 (m, 3H), 4.1 (s, 1H), 3.32 (s, 3H), 1.2 (s, 3H), 1.12 (s, 3H).

Aufarbeitung

  1. filtrationthe reaction mixture was filtered through a pad of celite
  2. customthe volatiles were removed under reduced pressure
  3. customThe residue thus obtained
  4. customwas further purified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-010482e02de149218431703cedb3e785
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09233979B2

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