Water → 4-Acetamido-3-iodobenzaldehyde

HRID 591679Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 591679
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([I:13])[CH:4]=1.O>CS(C)=O>[CH:2]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([I:13])[CH:4]=1)=[O:1]

Komponenten

4

Edukt 2

HCID 962WaterHCID 66745042N-(4-(Hydroxymethyl)-2-iodophenyl)acetamide

Produkt 1

HCID 229919464-Acetamido-3-iodobenzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

To a solution of IBX (0.93 g, 3.3 mmol) in dimethylsulfoxide (3.5 mL) was added N-(4-hydroxymethyl-2-iodo-phenyl)-acetamide (0.87 g, 3.0 mmol) and the reaction mixture was stirred at room temperature for 1 hour. Water (50 mL) was added and the solid was separated by filtration, and washed with ethyl acetate (20 mL). The filtrate was collected and extracted with ethyl acetate (200 mL). The organic phase was washed with brine (100 mL) and dried over anhydrous Na2SO4. Removal of solvent gave N-(4-formyl-2-iodo-phenyl)-acetamide as a light brown solid. Yield: 0.82 g (95%).

Aufarbeitung

  1. customthe solid was separated by filtration
  2. washwashed with ethyl acetate (20 mL)
  3. customThe filtrate was collected
  4. extractionextracted with ethyl acetate (200 mL)
  5. washThe organic phase was washed with brine (100 mL)
  6. dry with materialdried over anhydrous Na2SO4
  7. customRemoval of solvent

Quellen und Nachweise

ORD-Eintrag
ord-932f32110be646afa950cb72c7fb2cf3
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09238640B2

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