Sulfuric Acid → N-(5-amino-4-chloro-2-fluorobenzyl)-2,2,2-trifluoroacetamide

HRID 59387

Reaktionsgleichung

Reaktionsgleichung von HRID 59387
[F:1][C:2]([F:19])([F:18])[C:3]([NH:5][CH2:6][C:7]1[C:8]([F:17])=[CH:9][C:10]([Cl:16])=[C:11]([CH:15]=1)C(O)=O)=[O:4].OS(O)(=O)=O.[N-:25]=[N+]=[N-].[Na+]>>[NH2:25][C:11]1[C:10]([Cl:16])=[CH:9][C:8]([F:17])=[C:7]([CH:15]=1)[CH2:6][NH:5][C:3](=[O:4])[C:2]([F:19])([F:18])[F:1]

Komponenten

4

Edukt 3

HCID 1118Sulfuric AcidHCID 33557Sodium AzideHCID 897366685-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid

Produkt 1

HCID 90018998N-(5-amino-4-chloro-2-fluorobenzyl)-2,2,2-trifluoroacetamideAusbeute 64.668,398 %

Versuchsvorschrift

The title compound was prepared according to the procedure described in step-1 of Intermediate-57 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid (3.0 g), conc. H2SO4 and sodium azide (0.793 g, 0.012 mmol) to afford 2.1 g of the desired product.

Aufarbeitung

  1. customThe title compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-069b0936d7534524b20bdb7e804dfc9b
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09439890B2

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