Reaktionsgleichung
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([CH:6]([C:14]#[N:15])[CH2:7]C2C=CC=CC=2)=[CH:4][CH:3]=1.C([N-]C(C)C)(C)C.[Li+].[CH3:26][N:27]=[C:28]=[S:29]>O1CCCC1>[CH3:26][NH:27][C:28](=[S:29])[C:6]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:17][CH:16]=1)([C:14]#[N:15])[CH3:7]Komponenten
Versuchsvorschrift
To a 10 ml tetrahydrofuran solution containing 1.00 g (6 mmole) of 4-chlorophenylmethylbenzylcyanide was added a 3.2 ml tetrahydrofuran solution containing 2 M of lithium diisopropylamide at -60° C. After stirring for 30 minutes under the same conditions, a 5 ml tetrahydrofuran solution containing 0.44 g (6 mmol) of methyl isothiocyanate was added to the mixture and the mixture was allowed to stand at room temperature overnight. The solvent was removed from the reaction mixture under reduced pressure and water was added to the residue. The mixture was extracted with 50 ml of ethyl acetate, dried and condensed under reduced pressure, and then purified by silica gel chromatography and recrystallized from hexane to obtain 0.45 g (yield: 31.4 %) of N-methyl-2-(4-chlorophenyl)-2-cyano-thiopropionamide.
Aufarbeitung
- additionwas added to the mixture
- waitto stand at room temperature overnight
- customThe solvent was removed from the reaction mixture under reduced pressure and water
- additionwas added to the residue
- extractionThe mixture was extracted with 50 ml of ethyl acetate
- customdried
- customcondensed under reduced pressure
- custompurified by silica gel chromatography
- customrecrystallized from hexane
Quellen und Nachweise
- ORD-Eintrag
- ord-97a71ab8b30846a79c74a25e489cdea9
- Quelldatensatz
- uspto-grants-1993_09
- Patentnummer
- US05246958
Verknüpfte Notizen
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