(2-Chloro-5-(pyridin-2-yl)phenyl)methanol → 2-Chloro-5-(pyridin-2-yl)benzaldehyde

HRID 594221Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 594221
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:4][C:3]=1[CH2:14][OH:15]>C1COCC1.O=[Mn]=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:4][C:3]=1[CH:14]=[O:15]

Komponenten

4

Edukt 1

HCID 69083854(2-Chloro-5-(pyridin-2-yl)phenyl)methanol

Produkt 1

HCID 866956092-Chloro-5-(pyridin-2-yl)benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of (2-chloro-5-(pyridin-2-yl)phenyl)methanol (129 mg; 0.72 mmol) in anh. THF (7 ml) was treated with MnO2 (975 mg; 11.22 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 6.5 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with THF. The filtrate was concentrated to dryness under reduced pressure giving 2-chloro-5-(pyridin-2-yl)benzaldehyde as a yellow oil. LC-MS (conditions A): tR=0.43 min.; no ionisation.

Aufarbeitung

  1. customThe resulting reaction mixture
  2. filtrationwas then filtered over celite
  3. washthe separated solids were washed with THF
  4. concentrationThe filtrate was concentrated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e499c14df9794d05a477fcdfd2438064
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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