(3-(2H-1,2,3-triazol-2-yl)phenyl)methanol → 3-(2H-1,2,3-triazol-2-yl)benzaldehyde

HRID 594249Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 594249
[N:1]1[N:2]([C:6]2[CH:7]=[C:8]([CH2:12][OH:13])[CH:9]=[CH:10][CH:11]=2)[N:3]=[CH:4][CH:5]=1>C(Cl)Cl.O=[Mn]=O>[N:1]1[N:2]([C:6]2[CH:7]=[C:8]([CH:9]=[CH:10][CH:11]=2)[CH:12]=[O:13])[N:3]=[CH:4][CH:5]=1

Komponenten

4

Edukt 1

HCID 53488009(3-(2H-1,2,3-triazol-2-yl)phenyl)methanol

Produkt 1

HCID 834815283-(2H-1,2,3-triazol-2-yl)benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of (3-(2H-1,2,3-triazol-2-yl)phenyl)methanol (425 mg; 2.42 mmol) in anh. DCM (24 ml) was treated with MnO2 (3.165 g; 36.41 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 1.5 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 3-(2H-1,2,3-triazol-2-yl)benzaldehyde as a pale yellow solid. LC-MS (conditions A): tR=0.63 min.; no ionisation.

Aufarbeitung

  1. customThe resulting reaction mixture
  2. filtrationwas then filtered over celite
  3. washthe separated solids were washed with DCM
  4. concentrationThe filtrate was concentrated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-198db9f03f2b4a04a5a8423a71ed396e
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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