Water → HCID 86695629, Verbindung

HRID 594379Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 594379
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([CH3:11])=[N:8][C:7]=2[CH:12]=1.[K].[C:14]1(=[O:24])[NH:18][C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.O>CN(C=O)C>[CH3:11][C:9]1[O:10][C:6]2[CH:5]=[CH:4][C:3]([CH2:2][N:18]3[C:14](=[O:24])[C:15]4[C:16](=[CH:20][CH:21]=[CH:22][CH:23]=4)[C:17]3=[O:19])=[CH:12][C:7]=2[N:8]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 15662279136663-54-2HCID 24194345Phthalimide potassium salt

Produkt 1

HCID 86695629HCID 86695629, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 5-(bromomethyl)-2-methylbenzo[d]oxazole (400 mg; 1.76 mmol) in anh. DMF (2 ml) was treated portionwise with phthalimide potassium salt (327 mg; 1.76 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 18 h. Water was added, and the resulting precipitate was collected by filtration, and washed with water. Drying under HV afforded 2-((2-methylbenzo[d]oxazol-5-yl)methyl)isoindoline-1,3-dione as a brown solid. LC-MS (conditions E): tR=0.66 min.; [M+H]+: 293.15 g/mol.

Aufarbeitung

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with water
  3. customDrying under HV

Quellen und Nachweise

ORD-Eintrag
ord-d6a386c1d61d4c768a05675b352ec53d
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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