1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 5-(2,6-Dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

HRID 594614

Reaktionsgleichung

Reaktionsgleichung von HRID 594614
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[NH:15][C:14](=[O:16])[CH2:13][CH2:12]1.Br[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[N:15]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][C:26]([F:27])([F:28])[F:29])=[CH:21][CH:20]=2)[C:14](=[O:16])[CH2:13][CH2:12]1

Komponenten

3

Edukt 2

HCID 1427851-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 690809115-(2,6-Dimethoxyphenyl)pyrrolidin-2-one

Produkt 1

HCID 690850105-(2,6-Dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

Versuchsvorschrift

Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)pyrrolidin-2-one with commercially available 1-(bromomethyl)-4-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.80 min.; [M+H]+: 396.00 g/mol.

Aufarbeitung

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Quellen und Nachweise

ORD-Eintrag
ord-377e750005df4e2db93d27fc07a67fc4
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242970B2

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