Formic Acid → HCID 118597990, Verbindung

HRID 594793

Reaktionsgleichung

Reaktionsgleichung von HRID 594793
[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[CH2:3][O:2]1.[CH:11](O)=[O:12]>>[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH:10][CH:11]=[O:12])=[CH:9][C:4]=2[CH2:3][O:2]1

Komponenten

3

Edukt 2

HCID 284Formic AcidHCID 124453391,3-Dihydro-2-benzofuran-5-amine

Produkt 1

HCID 118597990HCID 118597990, VerbindungAusbeute 69 %

Versuchsvorschrift

1,3-Dihydro-2-benzofuran-5-amine (300 mg, 2.2 mmol) was added to HCOOH (10 mL), and the reaction was stirred at reflux overnight. The reaction was concentrated, basified to pH=8 with sat Na2CO3, and extracted with EtOAc. Organics were washed with brine, dried (Na2SO4), and concentrated to give 250 mg (69%) of N-(1,3-dihydro-2-benzofuran-5-yl)formamide as a yellow oil.

Aufarbeitung

  1. temperatureat reflux overnight
  2. concentrationThe reaction was concentrated
  3. extractionextracted with EtOAc
  4. washOrganics were washed with brine
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-2a377d8236184c4cb1970cc1c652a1d1
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09242968B2

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