Formic Acid → N-(1,3-dihydro-2-benzofuran-5-yl)formamide
Reaktionsgleichung
[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[CH2:3][O:2]1.[CH:11](O)=[O:12]>>[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH:10][CH:11]=[O:12])=[CH:9][C:4]=2[CH2:3][O:2]1Komponenten
3
Versuchsvorschrift
1,3-Dihydro-2-benzofuran-5-amine (300 mg, 2.2 mmol) was added to HCOOH (10 mL), and the reaction was stirred at reflux overnight. The reaction was concentrated, basified to pH=8 with sat Na2CO3, and extracted with EtOAc. Organics were washed with brine, dried (Na2SO4), and concentrated to give 250 mg (69%) of N-(1,3-dihydro-2-benzofuran-5-yl)formamide as a yellow oil.
Aufarbeitung
- temperatureat reflux overnight
- concentrationThe reaction was concentrated
- extractionextracted with EtOAc
- washOrganics were washed with brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-2a377d8236184c4cb1970cc1c652a1d1
- Quelldatensatz
- uspto-grants-2016_01
- Patentnummer
- US09242968B2
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