1,2-Dichloroethane → (5-Chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester

HRID 595088

Reaktionsgleichung

Reaktionsgleichung von HRID 595088
[C:1]([O:5][C:6]([N:8]([CH2:18][CH3:19])[C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:20]CCCl>>[C:1]([O:5][C:6](=[O:7])[N:8]([C:9]1[CH:17]=[CH:16][C:12]([C:13]([Cl:20])=[O:14])=[CH:11][N:10]=1)[CH2:18][CH3:19])([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 111,2-DichloroethaneHCID 667695526-(((Tert-butoxy)carbonyl)(ethyl)amino)pyridine-3-carboxylic acid

Produkt 1

HCID 86664610(5-Chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester

Versuchsvorschrift

6-(tert-Butoxycarbonyl-ethyl-amino)-nicotinic acid (6.40 g, 24.0 mmol) is taken up in 150 mL DCE, 1-chloro-N,N-2-trimethylpropenyl-amine (6.42 mL, 48.1 mmol) is added and the reaction mixture is stirred overnight at RT. The reaction mixture is concentrated under reduced pressure and the crude product is used in the next step without purification.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customthe crude product is used in the next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-068c5445f3374fb9b532cbba1e893995
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09243000B2

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