Sodium Iodide → HCID 20326649, Verbindung

Reaktionsgleichung

[C:1]1([C:7]2([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:13][CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:20][CH2:21][CH2:22][CH2:23][C:24]([C:26]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=1)=[O:25].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>>[ClH:20].[F:32][C:29]1[CH:28]=[CH:27][C:26]([C:24]([CH2:23][CH2:22][CH2:21][N:10]2[CH2:9][CH2:8][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[O:13][CH2:12][CH2:11]2)=[O:25])=[CH:31][CH:30]=1

Komponenten

Edukt 4

HCID 5238Sodium Iodide

HCID 11430Potassium Carbonate

HCID 197503-(4-Fluorobenzoyl)propyl chloride

HCID 203266297,7-Diphenyl-1,4-oxazepane

Produkt 1

HCID 20326649HCID 20326649, Verbindung

Versuchsvorschrift

The mixture of 3.20 g of 7,7-diphenyl-hexahydro-1,4-oxazepine, 2.54 g of 4-chloro-4'-fluoro-butyrophenone, 3.35 g of anhydrous potassium carbonate and 0.21 g of sodium iodide is refluxed for 22 hours, while stirring. The suspension is cooled, filtered, the filtrate evaporated and the residue dissolved in acetone. The solution is acidified with ethereal hydrogen chloride, to yield the 4-[3-(4-fluorobenzoyl)-propyl]-7,7-diphenylhexahydro-1,4-oxazepine hydrochloride melting at 137°-140°.