Sodium Iodide → N-2-ethyl-cyclohexylamino-3,4,5-trimethoxy-benzoate-hydrochloride

HRID 596235Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 596235
[Na].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([O:15][CH3:16])[C:12]=1[O:13][CH3:14])[C:7]([O-:9])=[O:8].Cl.[Cl:18][CH2:19][CH2:20][NH:21][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1.[I-].[Na+]>CN(C)C=O>[ClH:18].[CH3:19][CH2:20][N:21]([C:10]1[C:11]([O:15][CH3:16])=[C:12]([O:13][CH3:14])[C:4]([O:3][CH3:2])=[CH:5][C:6]=1[C:7]([OH:9])=[O:8])[CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Komponenten

5

Edukt 3

HCID 5238Sodium IodideHCID 13756691N-(2-chloroethyl)cyclohexanamine hydrochlorideHCID 86734526Sodium 3,4,5-trimethoxy-benzoate

Produkt 1

HCID 88821243N-2-ethyl-cyclohexylamino-3,4,5-trimethoxy-benzoate-hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To 1.7 g. of sodium-3,4,5-trimethoxy-benzoate 1.45 g. of N-2-chloroethyl-cyclohexylamine hydrochloride and some sodium iodide crystals are added, whereafter 30 ml. of dimethyl formamide are introduced. After cooling toe precipitated crystals are filtered and the filtrate is evaporated. The residue is recrystallized from 96% of ethanol under clarifying with activated charcoal. Thus N-2-ethyl-cyclohexylamino-3,4,5-trimethoxy-benzoate-hydrochloride is obtained. M.p.: 208°-210° C.

Aufarbeitung

  1. temperatureAfter cooling toe
  2. customprecipitated crystals
  3. filtrationare filtered
  4. customthe filtrate is evaporated
  5. customThe residue is recrystallized from 96% of ethanol

Quellen und Nachweise

ORD-Eintrag
ord-eaf5569218344429b65035dc5a7984e5
Quelldatensatz
uspto-grants-1977_03
Patentnummer
US04010193

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