Hydrogen Bromide → L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide

HRID 596809

Reaktionsgleichung

Reaktionsgleichung von HRID 596809
C(OC([NH:11][C@H:12]([C:23]([NH:25][C@H:26]([C:31]([NH:33][C@H:34]([C:39]([NH:41][CH:42]([C:46]([NH2:48])=[O:47])[CH2:43][CH2:44][CH3:45])=[O:40])[CH2:35][C:36](=[O:38])[OH:37])=[O:32])[CH2:27][CH2:28][S:29][CH3:30])=[O:24])[CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:16][CH:15]=1)=O)C1C=CC=CC=1.[BrH:49]>C(O)(=O)C.CSCC>[BrH:49].[NH2:11][C@H:12]([C:23]([NH:25][C@H:26]([C:31]([NH:33][C@H:34]([C:39]([NH:41][CH:42]([C:46]([NH2:48])=[O:47])[CH2:43][CH2:44][CH3:45])=[O:40])[CH2:35][C:36](=[O:37])[OH:38])=[O:32])[CH2:27][CH2:28][S:29][CH3:30])=[O:24])[CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:16][CH:15]=1

Komponenten

5

Edukt 2

HCID 260Hydrogen BromideHCID 22796407N-benzyloxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide

Produkt 1

HCID 22796390L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittel2×HCID 12230Ethyl methyl sulfideLösungsmittel

Versuchsvorschrift

N-benzyloxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide is dissolved in 10 parts glacial acetic acid containing 2 parts methylethyl sulfide. Then, 10 parts of 6 M hydrobromic acid in acetic acid is added and the solution is allowed to stand for one hour at room temperature. The solvents are removed under vacuum below 40° C. and the residue shaken with ether to afford L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide. This compound is represented by the following formula.

Aufarbeitung

  1. customThe solvents are removed under vacuum below 40° C.

Quellen und Nachweise

ORD-Eintrag
ord-8ac2eeb5e3e447358b5e3ac14dbce5f5
Quelldatensatz
uspto-grants-1977_03
Patentnummer
US04012367

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