Triethylamine → HCID 21448606, Verbindung

HRID 596871Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 596871
Cl[C:2]([C:4]([CH2:11][CH3:12])([CH2:9][CH3:10])[C:5]([O:7][CH3:8])=[O:6])=[O:3].C(N(CC)CC)C.[CH3:20][O:21][C:22](=[O:27])[CH2:23][CH2:24][NH:25][CH3:26]>CCOCC>[CH2:9]([C:4]([CH2:11][CH3:12])([C:2](=[O:3])[N:25]([CH3:26])[CH2:24][CH2:23][C:22]([O:21][CH3:20])=[O:27])[C:5]([O:7][CH3:8])=[O:6])[CH3:10]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 12414198Methyl N-methyl-beta-alaninateHCID 21448656HCID 21448656, Verbindung

Produkt 1

HCID 21448606HCID 21448606, VerbindungAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Reaktionsbedingungen

Temperatur
-10 °C

Versuchsvorschrift

To a solution of 19.2 g of methyl 2-chloroformyl-2-ethyl-butyrate and 20 g of triethylamine in 100 ml of dry ether, which is mechanically stirred and cooled at -10° C, there is added dropwise 12.8 g of N-methyl-β-alanine methyl ester dissolved in 50 ml of dry ether. After the addition, which takes 30 minutes, the mixture is stirred during 18 hours at room temperature. After filtration of the separated triethylamine hydrochloride, the solvent is evaporated leaving the desired product as an oil, boiling at 118° C (0.2 mm). Yield 93%. nD19 1.4646.

Aufarbeitung

  1. additionAfter the addition, which
  2. filtrationAfter filtration of the separated triethylamine hydrochloride
  3. customthe solvent is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-9b25783c665246b386d839daaff9011c
Quelldatensatz
uspto-grants-1977_03
Patentnummer
US04012392

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