3-Chloropropionitrile → 3-(3-Trifluoromethylphenylthio)-propionitrile

HRID 597392

Reaktionsgleichung

Reaktionsgleichung von HRID 597392
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([SH:9])[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+].Cl[CH2:15][CH2:16][C:17]#[N:18]>O>[F:11][C:2]([F:1])([F:10])[C:3]1[CH:4]=[C:5]([S:9][CH2:15][CH2:16][C:17]#[N:18])[CH:6]=[CH:7][CH:8]=1

Komponenten

5

Edukt 3

HCID 109633-ChloropropionitrileHCID 14798Sodium HydroxideHCID 1367513-(Trifluoromethyl)benzenethiol

Produkt 1

HCID 198439363-(3-Trifluoromethylphenylthio)-propionitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 15.9 g (0.09 mol) of 3-trifluoromethylthiophenol and 3.8 g (0.095 mol) of sodium hydroxide pellets in 100 ml of water is heated at 65°-70° C and 8.5 g (0.095 mol) of β-chloropropionitrile are added dropwise whilst stirring. The mixture is heated for a quarter of an hour to the reflux temperature and is then cooled and extracted with ether, and the extract is washed with water and dried with magnesium sulphate. This gives 3-(3-trifluoromethylphenylthio)-propionitrile, which is not isolated.

Aufarbeitung

  1. temperatureThe mixture is heated for a quarter of an hour to the reflux temperature
  2. temperatureis then cooled
  3. extractionextracted with ether
  4. washthe extract is washed with water
  5. dry with materialdried with magnesium sulphate

Quellen und Nachweise

ORD-Eintrag
ord-56a53ea130574dc8acfa973d562739c3
Quelldatensatz
uspto-grants-1977_03
Patentnummer
US04013776

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