Bromine → N-[3-(Bromoacetyl)phenyl]acetamide

HRID 597567

Reaktionsgleichung

Reaktionsgleichung von HRID 597567
[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[NH:7][C:8](=[O:10])[CH3:9])(=[O:3])[CH3:2].[Br:14]Br>C(Cl)(Cl)Cl>[Br:14][CH2:2][C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[NH:7][C:8](=[O:10])[CH3:9])=[O:3]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 3462023'-Acetamidoacetophenone

Produkt 1

HCID 12431847N-[3-(Bromoacetyl)phenyl]acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 110.0 g. (0.62 mole) of 3'-acetylacetanilide in 2400 ml. of chloroform is added dropwise a solution of 33.0 ml. (102.9 g; 0.644 mole) of bromine in 240 ml. of chloroform. The solution is stirred one hour and the resultant precipitate is then filtered, washed with ether and dried. The solid is stirred in a large volume of water to give an oily precipitate which crystallizes on further stirring. The solid is filtered, washed with water and then 2-propanol. The dried product weighs 148.34 g., and is recrystallized from 2-propanol to give the product, melting point 108.5°-110° C. Analysis: Calcd, for C10H10BrNO2 : Calcd: C, 46.90; H, 3.94; Br, 31.20; N, 5.47. Found: C, 47.12; H, 3.94; Br, 31.21; N, 5.47.

Aufarbeitung

  1. filtrationthe resultant precipitate is then filtered
  2. washwashed with ether
  3. customdried
  4. stirringThe solid is stirred in a large volume of water
  5. customto give an oily precipitate which
  6. customcrystallizes on further stirring
  7. filtrationThe solid is filtered
  8. washwashed with water
  9. custom, and is recrystallized from 2-propanol
  10. customto give the product, melting point 108.5°-110° C

Quellen und Nachweise

ORD-Eintrag
ord-de425ded540241f9953b6087d2c3a356
Quelldatensatz
uspto-grants-1977_03
Patentnummer
US04014892

Verknüpfte Notizen

Wird geladen…