Water → HCID 57438270, Verbindung

HRID 598404Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 598404
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][NH:5][C:4](=[O:11])[CH:3]=1.[F:12][C:13]1[CH:19]=[C:18]([I:20])[CH:17]=[CH:16][C:14]=1[NH2:15].O>CCO.Cl>[F:12][C:13]1[CH:19]=[C:18]([I:20])[CH:17]=[CH:16][C:14]=1[NH:15][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][NH:5][C:4](=[O:11])[CH:3]=1

Komponenten

6

Edukt 3

HCID 962WaterHCID 1856942-Fluoro-4-iodoanilineHCID 426090674-Chloro-5-nitropyridin-2(1H)-one

Produkt 1

HCID 57438270HCID 57438270, VerbindungAusbeute 45 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidKatalysatorHCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To the mixture of 4-chloro-5-nitropyridin-2(1H)-one (90.1 mg, 0.517 mmol) and 2-fluoro-4-iodoaniline (137.5 mg, 0.58 mmol) dissolved in EtOH (5 mL) was added 6 drops of HCl (37% wt in water). The reaction vessel was closed and heated at 90° C. for 48 hours. After cooling to room temperature, water was added, and the solution was stirred at room temperature for 20 min. The precipitate was filtered, washed with water, dried under vacuum and used for the next reaction without further purification. (87.3 mg, 45% yield).

Aufarbeitung

  1. customThe reaction vessel was closed
  2. temperatureAfter cooling to room temperature
  3. filtrationThe precipitate was filtered
  4. washwashed with water
  5. customdried under vacuum
  6. customused for the next reaction without further purification

Quellen und Nachweise

ORD-Eintrag
ord-62f399ff62994252ba8f20e2dd55170b
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07897624B2

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