Morpholine → 4-(4-Nitropyridin-2-yl)morpholine

HRID 598716

Reaktionsgleichung

Reaktionsgleichung von HRID 598716
[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>C1COCC1>[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=1)([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 707344-Nitropyridine

Produkt 1

HCID 574185464-(4-Nitropyridin-2-yl)morpholineAusbeute 56,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2-chloro, 4-nitropyridine (0.2 g, 1.27 mmol) in THF (3 mL) was added morpholine (328 mg, 38.1 mmol). The reaction was heated to 80 C and stirred overnight. The solvent was evaporated and the residue purified by column chromatography (2/1 Hex/EtOAc) to yield 150 mg of the target compound.

Aufarbeitung

  1. temperatureThe reaction was heated to 80 C
  2. customThe solvent was evaporated
  3. customthe residue purified by column chromatography (2/1 Hex/EtOAc)

Quellen und Nachweise

ORD-Eintrag
ord-e456b857d97c47feae59f8a0e57888c7
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07897599B2

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