Lithium Hydroxide → HCID 118366184, Verbindung

HRID 59921Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 59921
[CH2:1]([O:3][C:4]1[CH:25]=[CH:24][CH:23]=[CH:22][C:5]=1[O:6][C@@H:7]1[CH2:12][CH2:11][CH2:10][N:9]([C:13]2[N:18]=[CH:17][C:16]([C:19](O)=[O:20])=[CH:15][N:14]=2)[CH2:8]1)[CH3:2].[NH2:26][CH2:27][C:28]1[C:29]([CH3:39])=[N:30][CH:31]=[C:32]([CH:38]=1)[C:33]([O:35]CC)=[O:34].CCN=C=NCCCN(C)C.Cl.[Li+].[OH-]>>[CH2:1]([O:3][C:4]1[CH:25]=[CH:24][CH:23]=[CH:22][C:5]=1[O:6][C@@H:7]1[CH2:12][CH2:11][CH2:10][N:9]([C:13]2[N:18]=[CH:17][C:16]([C:19]([NH:26][CH2:27][C:28]3[C:29]([CH3:39])=[N:30][CH:31]=[C:32]([CH:38]=3)[C:33]([OH:35])=[O:34])=[O:20])=[CH:15][N:14]=2)[CH2:8]1)[CH3:2]

Komponenten

5

Edukt 4

HCID 3939Lithium HydroxideHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 118366162Ethyl 5-(aminomethyl)-6-methylnicotinateHCID 118366221(R)-2-(3-(2-ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic acid

Produkt 1

HCID 118366184HCID 118366184, Verbindung

Versuchsvorschrift

(R)-5-((2-(3-(2-ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxamido)methyl)-6-methylnicotinic acid was prepared from (R)-2-(3-(2-ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic acid and ethyl 5-(aminomethyl)-6-methylnicotinate using Amidation Method 2 (EDCl) and Ester Hydrolysis Method 1 (LiOH). 1H NMR (400 MHz, DMSO-d6) δ 9.17 (m, 1H), 8.95 (s, 1H), 8.80 (s, 2H), 8.45 (m, 1H), 7.03 (d, 1H), 6.90 (m, 3H), 4.58 (d, 2H), 4.35 (m, 1H), 4.12 (m, 1H), 3.90 (m, 5H), 2.79 (s, 3H), 2.03 (m, 1H), 1.87 (m, 2H), 1.52 (m, 1H), 1.21 (t, 3H). MS (ES+) 492.2 (M+H).

Quellen und Nachweise

ORD-Eintrag
ord-7f1ee38596e94f81aee5687f5b66b0f2
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440949B2

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