Sulfuric Acid → HCID 68322517, Verbindung

HRID 59942

Reaktionsgleichung

Reaktionsgleichung von HRID 59942
OS(O)(=O)=O.N[C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][C:8]=1[CH2:15][CH3:16].N([O-])=[O:18].[Na+]>O>[CH2:15]([C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][C:7]=1[OH:18])[C:11]#[N:12])[CH3:16]

Komponenten

5

Edukt 3

HCID 1118Sulfuric AcidHCID 27353304-Amino-3-ethylbenzonitrileHCID 23668193Sodium Nitrite

Produkt 1

HCID 68322517HCID 68322517, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Concentrated H2SO4 (3.4 mL) was added dropwise to a solution of 4-amino-3-ethylbenzonitrile (6.84 mmol) in H2O (12 mL) at 0° C. A solution of NaNO2 (7.52 mmol) in H2O (5 mL) was added dropwise at 0° C. to the resulting mixture. The reaction was stirred at 0° C. for 30 min and at 100° C. for 2 h. The mixture was cooled to room temperature and extracted with EtOAc. The organic layer was washed (H2O), dried and concentrated to yield the desired product.

Aufarbeitung

  1. temperatureThe mixture was cooled to room temperature
  2. extractionextracted with EtOAc
  3. washThe organic layer was washed (H2O)
  4. customdried
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-33b4df3f08864a06bc6dd8ba3ccfe5e1
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440929B2

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