4-(4-Benzylpiperazin-1-yl)-1lambda6-thiane-1,1-dione → 1-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)piperazine

HRID 599728Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 599728
C([N:8]1[CH2:13][CH2:12][N:11]([CH:14]2[CH2:19][CH2:18][S:17](=[O:21])(=[O:20])[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[O:21]=[S:17]1(=[O:20])[CH2:16][CH2:15][CH:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH2:19][CH2:18]1

Komponenten

5

Edukt 2

HCID 672737414-(4-Benzylpiperazin-1-yl)-1lambda6-thiane-1,1-dioneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 467858481-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)piperazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 0.57 g (1.85 mmol) 1-benzyl-4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-piperazine and 300 mg 10% Pd/C in 30 mL MeOH was hydrogenated at 50° C. and 50 psi hydrogen pressure for 10 h. The catalyst was removed by suction filtering and the filtrate was concentrated by evaporation i. vac. The product was reacted further without purification.

Aufarbeitung

  1. customwas hydrogenated at 50° C.
  2. customThe catalyst was removed by suction
  3. filtrationfiltering
  4. concentrationthe filtrate was concentrated by evaporation i
  5. customThe product was reacted further without purification

Quellen und Nachweise

ORD-Eintrag
ord-43f4e1a5a2ed4b30926e2096083b608d
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07897603B2

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