Hydrochloric Acid → 1,2,3,4,6,11-Hexapropyl-5,12-dihydrotetracene

HRID 600142

Reaktionsgleichung

Reaktionsgleichung von HRID 600142
[CH2:1]([C:7]1[C:16]([CH2:17][C:18]#[C:19][CH2:20][CH2:21][CH3:22])=[C:15]([CH2:23][CH2:24][CH3:25])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]=1[CH2:26][CH2:27][CH3:28])[C:2]#[C:3][CH2:4][CH2:5][CH3:6].C([Li])[CH2:30][CH2:31][CH3:32].[CH3:34][CH2:35][CH2:36]C#CCCC.Cl.[CH2:43]1COC[CH2:44]1>>[CH2:20]([C:19]1[C:18]2[CH2:17][C:16]3[C:7](=[C:8]([CH2:26][CH2:27][CH3:28])[C:9]4[C:14]([C:15]=3[CH2:23][CH2:24][CH3:25])=[CH:13][CH:12]=[CH:11][CH:10]=4)[CH2:1][C:2]=2[C:3]([CH2:30][CH2:31][CH3:32])=[C:4]([CH2:34][CH2:35][CH3:36])[C:5]=1[CH2:6][CH2:43][CH3:44])[CH2:21][CH3:22]

Komponenten

6

Edukt 5

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 160294-OctyneHCID 113946772,3-Bis(2-hexynyl)-1,4-dipropylnaphthaleneHCID 178418339Butyllithium

Produkt 1

HCID 178395091,2,3,4,6,11-Hexapropyl-5,12-dihydrotetraceneAusbeute 46 %

Versuchsvorschrift

2,3-Bis(2-hexynyl)-1,4-dipropylnaphthalene (0.373 g, 1.0 mmol) was added at −78° C. to a 20 ml THF solution of bis(i5-cyclopentadienyl)dibutylzirconium, which was prepared from bis(η5-cyclopentadienyl)dichlorozirconium (0.351 g, 1.2 mmol) and n-butyl lithium (1.5 ml, 2.4 mmols, 1.6 M). After elevating to room temperature, the reaction mixture was stirred for an hour. 4-Octyne (0.22 ml, 1.5 mmol) and NiBr2(PPh3)2 (0.892 g, 1.2 mmol) were added to the reaction mixture at room temperature. After stirring for 24 hours, hydrolysis was effected by 3N HCl followed by extraction with hexane. The extract was washed with sodium hydrogencarbonate aqueous solution and brine followed by drying over anhydrous magnesium sulfate. Column chromatography was performed using silica gel as the packing material to give the title compound (0.224 g) as somewhat orange powders by floured with ethanol. The isolation yield was 46%.

Aufarbeitung

  1. customAfter elevating to room temperature
  2. stirringAfter stirring for 24 hours
  3. customhydrolysis
  4. extractionfollowed by extraction with hexane
  5. washThe extract was washed with sodium hydrogencarbonate aqueous solution and brine
  6. dry with materialby drying over anhydrous magnesium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-aab044d75960450bbc543654efb1a860
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07901594B2

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