Sodium Sulfite → Sodium (2-methylthiazol-4-yl)methanesulfonate

HRID 60045

Reaktionsgleichung

Reaktionsgleichung von HRID 60045
Cl[CH2:2][C:3]1[N:4]=[C:5]([CH3:8])[S:6][CH:7]=1.[S:9]([O-:12])([O-:11])=[O:10].[Na+:13].[Na+]>O>[CH3:8][C:5]1[S:6][CH:7]=[C:3]([CH2:2][S:9]([O-:12])(=[O:11])=[O:10])[N:4]=1.[Na+:13]

Komponenten

4

Edukt 2

HCID 24437Sodium SulfiteHCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazole

Produkt 1

HCID 59464713Sodium (2-methylthiazol-4-yl)methanesulfonateAusbeute 101,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

4-Chloromethyl-2-methylthiazole (250 mg, 1.69 mmol) is dissolved in H2O (2 mL) and treated with sodium sulfite (224 mg, 1.78 mmol). The reaction mixture is subjected to microwave irradiation for 20 minutes at 200° C. The reaction mixture is diluted with H2O (30 mL) and washed with EtOAc (2×25 mL). The aqueous layer is concentrated to afford 0.368 g of the desired product as a yellow solid. LC/MS ESI+ 194 (M+1, free acid).

Aufarbeitung

  1. customirradiation for 20 minutes at 200° C
  2. washwashed with EtOAc (2×25 mL)
  3. concentrationThe aqueous layer is concentrated

Quellen und Nachweise

ORD-Eintrag
ord-2dee5aeb32ce49538fa9567ca188082d
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440963B2

Verknüpfte Notizen

Wird geladen…