Hydrazine → HCID 178446231, Verbindung

HRID 600567Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 600567
CS[C:3]1[C:4]2[NH:5][C:6]([C:18]([F:21])([F:20])[F:19])=[N:7][C:8]=2[N:9]([CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:10](=[O:12])[N:11]=1.[NH2:22][NH2:23]>O>[CH2:13]([N:9]1[C:8]2[N:7]=[C:6]([C:18]([F:21])([F:20])[F:19])[NH:5][C:4]=2/[C:3](=[N:22]\[NH2:23])/[NH:11][C:10]1=[O:12])[CH2:14][CH2:15][CH2:16][CH3:17]

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 59853838HCID 59853838, Verbindung

Produkt 1

HCID 178446231HCID 178446231, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 6-(methylthio)-3-pentyl-8-(trifluoromethyl)-3,7-dihydro-2H-purin-2-one (0.15 g, 0.23 mmol) and hydrazine (0.80 mL, 25 mmol) in water (0.80 mL) was heated at 100° C. for 1 h. The solution was concentrated under reduced pressure and azeotropically treated with toluene twice. The resulting residue was used for next step without purification. LCMS calculated for C11H16F3N6O (M+H): 305.1. found: 305.1.

Aufarbeitung

  1. concentrationThe solution was concentrated under reduced pressure
  2. additionazeotropically treated with toluene twice
  3. customThe resulting residue was used for next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-a37cc20cd1164cb8af7242fb35e9c962
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07902205B2

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