Nitric Acid → HCID 178503569, Verbindung

HRID 60183

Reaktionsgleichung

Reaktionsgleichung von HRID 60183
[CH3:1][S:2][C:3]1[N:8]=[C:7]([OH:9])[CH:6]=[C:5]([OH:10])[N:4]=1.[N+:11]([O-])([OH:13])=[O:12]>C(O)(=O)C>[CH3:1][S:2][C:3]1[N:8]=[C:7]([OH:9])[C:6]([N+:11]([O-:13])=[O:12])=[C:5]([OH:10])[N:4]=1

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 178503559HCID 178503559, Verbindung

Produkt 1

HCID 178503569HCID 178503569, VerbindungAusbeute 49 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

2-Methylsulfanyl-pyrimidine-4,6-diol (10 g, 63 mmol) was added portion wise to a stirring solution of glacial acetic acid (25 mL) and concentrated nitric acid (10 mL) at 50° C. After 3 h, the reaction mixture was poured onto crushed ice and the product was isolated by filtration as a yellow solid (6 g, 49%). MS (ESI, negative mode): mass calcd. for C5H5N3O4S, 203.0; m/z found, 202.4 [M−H].

Aufarbeitung

  1. additionthe reaction mixture was poured
  2. customonto crushed ice

Quellen und Nachweise

ORD-Eintrag
ord-972279b8364a449fa4f851d83a90a525
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440978B2

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