1-(Benzyloxycarbonyl)-3-(tert-butyldimethylsilyloxymethyl)piperidine → Tert-butyl-dimethyl-(3-piperidylmethoxy)silane

HRID 602124Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 602124
C(OC([N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([CH2:17][O:18][Si:19]([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20])[CH2:12]1)=O)C1C=CC=CC=1.[H][H]>[Pd].CO>[Si:19]([O:18][CH2:17][CH:13]1[CH2:14][CH2:15][CH2:16][NH:11][CH2:12]1)([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20]

Komponenten

5

Edukt 2

HCID 589926311-(Benzyloxycarbonyl)-3-(tert-butyldimethylsilyloxymethyl)piperidineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 58992622Tert-butyl-dimethyl-(3-piperidylmethoxy)silaneAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

10% palladium on activated carbon (1.32 g) was added to 1-(benzyloxycarbonyl)-3-(tert-butyldimethylsilyloxymethyl)piperidine (13.2 g, 36.3 mmol) in methanol (130 mL). The mixture was stirred at room temperature for 1 hour in a hydrogen atmosphere. Subsequently, the mixture was filtered through Celite, followed by evaporation of the solvent to give 7.96 g (96%) of the desired compound as a colorless oil.

Aufarbeitung

  1. filtrationSubsequently, the mixture was filtered through Celite
  2. customfollowed by evaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-0b0a62a655e34190b0f76ee0e67e51cb
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07902367B2

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